Overview:

LATS2 is a serine/threonine protein kinase belonging to the LATS tumor suppressor family (1). The kinase activity and two conserved domains within LATS2 are responsible for the suppression of tumorigenicity and inhibition of cell growth. LATS2 negatively regulates the cell cycle by controlling G1/S and/or G2/M transition. LATS2 interacts with the centrosomal proteins AURORA A and Ajuba and is required for accumulation of γ-tubulin and spindle formation at the onset of mitosis (2). LATS2 also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. LATS2 can also function as a co-repressor of androgen-responsive gene expression.

Gene Aliases:

KPM, FLJ13161

Genbank Number:

NM_014572

References:

1. Li, Y. et al: Lats2, a putative tumor suppressor, inhibits G1/S transition. Oncogene. 2003; 22(28):4398-405.

2. Yabuta, N. et al: Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts. Genomics. 2000 63(2):263-70.