Overview:

FLT1, also known as fms-like tyrosine kinase 1, is a member of the VEGFR family and is related to the oncogene ROS (1). The tyrosine kinase activity of FLT1 has been shown to play a key role in control of cell proliferation and differentiation. FLT1 is a receptor for vascular endothelial growth factor (VEGF) and it has been observed that the ratio of FLT1 mRNA to VEGF mRNA correlates with tumor angiogenesis and prognosis in non-small cell lung cancers (2). In addition to the full-length receptor, FLT1 gene also encodes a soluble form of receptor due to alternative splicing. Both the full length and soluble form of FLT1 show strong binding affinity for VEGF.

Gene Aliases:

FLT, VEGFR1

Genbank Number:

NM_002019

References:

1. Autiero, M. et al: Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1. Nature, 2003; 9: 936-943.

2. Fong, G.-H. et al: Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature,1995; 376: 65-69.