Recombinant human ASK1 full length was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M13-10G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| M13-10G-05 | 5 ug | $435 | |
| M13-10G-10 | 10 ug | $655 | |
| M13-10G-BULK | BULK | Contact Us |
Overview:
ASK1, also known as MAPKKK5, activates MKK3, MKK4 (SEK1), and MKK6. Overexpression of ASK1 induces apoptotic cell death, and ASK1 is activated in cells treated with tumor necrosis factor-alpha (1). ASK1 interacts with members of the TRAF family and is activated by TRAF2 in the TNF-signaling pathway. After activation by TRAF2, ASK1 activates MKK4, which in turn activates JNK. Thus, ASK1 is a mediator of TRAF2-induced JNK activation (2).
Gene Aliases:
MAP3K5; MEKK5; MAPKKK5
Genbank Number:
References:
1. Ichijo, H. et al: Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science 275: 90-94, 1997.
2. Nishitoh, H. et al: ASK1 is essential for JNK/SAPK activation by TRAF2. Molec. Cell 2: 389-395, 1998.
Specific Activity:
Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
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Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~160 kDa
There are no related publications available for this product.
Apoptosis/Autophagy, Cancer, Cellular Stress, JNK/SAPK Pathway, p38 Pathway, Ser/Thr Kinases
Kinase Dilution Buffer X, K20-09
Kinase Assay Buffer III, K03-09
Kinase Dilution Buffer IX, K29-09
MEK6 (MAP2K6), Unactive, M07-14H
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