Recombinant human ACVR2A (161-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Catalog No. A35-11H
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| A35-11H-05 | 5 ug | $226 | |
| A35-11H-10 | 10 ug | $325 | |
| A35-11H-BULK | BULK | Contact Us |
Overview:
Activins are dimeric growth and differentiation factors which belong to the TGF-beta superfamily of structurally related signaling proteins that signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors (1). ACVR2A is highly expressed in human brain and ovary and may be associated with susceptibility to preeclampsia (2). ACVR2A is a transmembrane protein, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic kinase domain with predicted serine/threonine specificity.
Gene Aliases:
ACTRII; ACVR2
Genbank Number:
References:
1. Donaldson, C. J. et.al: Molecular cloning and binding properties of the human type II activin receptor. Biochem. Biophys. Res. Commun. 184: 310-316, 1992.
2. Peng, C. et.al: Expression of the type II activin receptor gene in the human placenta. Endocrinology 133: 3046-3049, 1993.
Activity:
Sample activity data. For lot specific data, please refer to specific datasheet.
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Purity:
Sample purity data. for lot specific data please refer to the specific datasheet.
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Molecular Weight:
Approx. MW 47 kDa.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
There are no related publications available for this product.
Cancer, Cell Cycle, Cellular Stress, Ser/Thr Kinases
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