Recombinant mouse TTBK2 (70-538) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. T18-11G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
T18-11G-05 | 5 ug | $226 | |
T18-11G-10 | 10 ug | $325 | |
T18-11G-BULK | BULK | Contact Us |
Overview:
TTBK2 or tau tubulin kinase 2 is a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. TTBK2 is a member of the casein kinase (CK1) group of eukaryotic protein kinases that is involved in tau phosphorylation and aggregation (1). Mutations in TTBK2 cause spinocerebellar ataxia type 11 (SCA11) (a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem) (2).
Gene Aliases:
mKIAA0847; TTBK; TTBK1; TTK
Genbank Number:
References:
1. Sato, S. et: Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation. J. Neurochem. 98: 1573-1584, 2006.
2. Houlden, H. et.al: Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11. Nature Genet. 39: 1434-1436, 2007.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~88 kDa
F. Liachko Nicole et al., CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration Annals of Neurology February 2013 10.1002/ana.23870
F. Liachko Nicole et al., The Tau Tubulin Kinases TTBK1/2 Promote Accumulation of Pathological TDP-43 PLoS Genetics December 2014 10.1371/journal.pgen.1004803
Richard Rubenstein et al., A novel, ultrasensitive assay for tau: potential for assessing traumatic brain injury in tissues and biofluids Journal of Neurotrauma March 2016 10.1089/neu.2014.3548
R Rubenstein et al., A Novel, Ultrasensitive Assay for Tau: Potential for Assessing Traumatic Brain Injury in Tissues and Biofluids Journal of Neurotrauma March 2015 10.1089/neu.2014.3548
Young Leea Jin et al., Celastrol blocks binding of lipopolysaccharides to a Toll-like receptor4/myeloid differentiation factor2 complex in a thiol-dependent manner Journal of Ethnopharmacology August 2015 10.1016/j.jep.2015.06.028
Invasion/Metastasis, Neurobiology, p38 Pathway, Ser/Thr Kinases
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