Recombinant full-length human LKB1(STK11) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. L15-30G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| L15-30G-20 | 20 ug | $215 | |
| L15-30G-50 | 50 ug | $435 | |
| L15-30G-BULK | BULK | Contact Us |
Overview:
LKB1(STK11) is a member of the serine/threonine kinase family which regulates cell polarity and functions as a tumor suppressor. STK11 is a critical barrier to pulmonary tumorigenesis which controlling initiation, differentiation, and metastasis. STK11 plays a central role in restricting HSC entry into cell cycle and in broadly maintaining energy homeostasis in hematopoietic cells through a novel metabolic checkpoint (1). STK11 serves as an essential regulator of HSCs and hematopoiesis, and more generally, points to the critical importance of coupling energy metabolism and stem cell homeostasis (2).
Gene Aliases:
STK11, LKB1, PJS
Genbank Number:
References:
1. Gurumurthy, S. et.al: The Lkb1 metabolic sensor maintains haematopoietic stem cell survival. Nature 468: 659-663, 2010. Note: Erratum: Nature 476: 114 only, 2011.
2. Gan, B.et.al: Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells. Nature 468: 701-704, 2010.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~85 kDa
Apoptosis/Autophagy, Cancer, Metabolic Disorder, Ser/Thr Kinases
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Q Zhu et al., Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis. Journal of Clinical Investigation November 2016 10.1172/JCI85510
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