SIK3, Active
Recombinant human SIK3 (1-307) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. S12-11G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| S12-11G-05 | 5 ug | $226 | |
| S12-11G-10 | 10 ug | $325 | |
| S12-11G-BULK | BULK | Contact Us |
Recombinant human SIK3 (1-307) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. S12-11G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| S12-11G-05 | 5 ug | $226 | |
| S12-11G-10 | 10 ug | $325 | |
| S12-11G-BULK | BULK | Contact Us |
Overview:
SIK3 (QSK) is a serine/threonine-protein kinase, belongs to QIK subfamily. The phosphorylation of SIK3 by LKB1 through the 14-3-3 binding enhances its catalytic activity and leads its localization to punctate structures within the cytoplasm (1). Overexpression of SIK3 promotes G1/S cell cycle progression with ovarian cancer (2). There are two sites (H331L and A1103V) were mutated at significant frequency in breast cancer (3). SIK3 is a novel tumor-associated antigen (TAA).
Gene Aliases:
QSK; SIK-3; L19; FLJ12240; KIAA0999
Genbank Number:
References:
1. Al-Hakim A.K., et.al: 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK. J. Cell Sci. 118:5661-5673(2005).
2. Charoenfuprasert S, et.al: Identification of salt-inducible kinase 3 as a novel tumor antigen associated with tumorigenesis of ovarian cancer. Oncogene. 2011 Aug 18;30(33):3570-84.
3. Sjoeblom T. et.al: The consensus coding sequences of human breast and colorectal cancers. Science 314:268-274(2006).
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
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Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~62 kDa
Product Datasheets
Cancer, Ser/Thr Kinases
Kinase Dilution Buffer III, K23-09
ATP Stock Solution, A50-09
AMARA Peptide, A11-58
SIK, Active, S14-10G
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