Recombinant full-length human RSK1 was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Catalog No. R15-10G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| R15-10G-05 | 5 ug | $226 | |
| R15-10G-10 | 10 ug | $325 | |
| R15-10G-BULK | BULK | Contact Us |
Overview:
RSK1 is a member of the RSK (ribosomal S6 kinase) family that are growth factor-regulated serine/threonine kinases. RSK1 contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. RSK1 encodes a predicted 735-amino acid protein containing 2 distinct consensus ATP-binding site sequences. RSK1 transcript is present in lymphocytes, skeletal muscle, liver, and adipose tissue (1). RSKs are implicated in the activation of the mitogen-activated kinase (MAPK) cascade and the stimulation of cell proliferation and differentiation (2).
Gene Aliases:
RPS6KA1; HU-1; MAPKAPK1A; S6K-alpha 1
Genbank Number:
References:
1. Moller, D E. et al: Human rsk isoforms: cloning and characterization of tissue-specific expression. Am. J. Physiol. 266: C351-C359, 1994.
2. Gross, S D. et al: Induction of metaphase arrest in cleaving Xenopus embryos by the protein kinase p90(Rsk). Science 286: 1365-1367, 1999.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet
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Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~108 kDa
MJ Lommel et al., L-plastin Ser5 phosphorylation breast cancer cells and in vitro is mediated by RSK downstream of the ERK/MAPK pathway. FASEB Journal March 2016 10.1096/fj.15-276311
Yanga Shuping et al., Phosphorylation of KIBRA by the extracellular signal-regulated kinase (ERK)?ribosomal S6 kinase (RSK) cascade modulates cell proliferation and migration Cellular Signaling February 2014 10.1016/j.cellsig.2013.11.012
M. Reipas Kristen et al., Luteolin is a novel p90 ribosomal S6 kinase (RSK) inhibitor that suppresses Notch4 signaling by blocking the activation of Y-box binding protein-1 (YB-1). Oncotarget February 2014 10.18632/oncotarget.834
A. Everley Robert et al., Increasing Throughput in Targeted Proteomics Assays: 54-Plex Quantitation in a Single Mass Spectrometry Run Analytical Chemistry May 2013 10.1021/ac400845e
A. Galana Jacob et al., Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3 PNAS April 2014 10.1073/pnas.1405601111
et al., RIOK2 phosphorylation by RSK promotes synthesis of the human small ribosomal subunit PLoS Genetics June 2021
et al., Serine 897 Phosphorylation of EPHA2 Is Involved in Signaling of Oncogenic ERK1/2 Drivers in Thyroid Cancer Cells. Thyroid : official journal of the American Thyroid Association September 2020
Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Inflammation, Neurobiology, NfkB Pathway, Ser/Thr Kinases
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