Recombinant human full-length PFTK1 (CDK14) and Cyclin Y (2-end) were co-expressed by baculovirus in Sf9 insect cells using N-terminal GST tags.
Catalog No. P15-10G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| P15-10G-05 | 5 ug | $259 | |
| P15-10G-10 | 10 ug | $380 | |
| P15-10G-BULK | BULK | Contact Us |
Overview:
PFTK1 is a member of the CDC2 - related protein kinase family which is expressed primarily in the postnatal and adult nervous system (1). PFTK1 is expressed at high levels in brain, pancreas, kidney, heart, testis, and ovary. PFTK1 amino acid residue ser119 is required for its interaction with all four 14-3-3 isoforms, while ser120 may contribute slightly to PFTK1 binding (2). PFTK1 acts as a cyclin-dependent kinase that regulates cell cycle progression and cell proliferation. Overexpression of PFTK1 predicts resistance to chemotherapy in patients with oesophageal squamous cell carcinoma.
Gene Aliases:
PFTK1: CDK14; PFTAIRE1 Cyclin Y: CCNY; C10orf9; CBCP1; CCNX; CFP1
References:
1. Yang, T. et.al: Identification and cellular localization of human PFTAIRE1. Gene 267: 165-172, 2001.
2. Gao, Y. et.al: A Cdc2-related protein kinase hPFTAIRE1 from human brain interacting with 14-3-3 proteins. Cell Res. 16: 539-547, 2006.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
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Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
PFTK1 (CDK14) ~72 kDa and Cyclin Y ~64 kDa
Bhandaria Deepali et al., Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration?proliferation dichotomy PNAS July 2015 10.1073/pnas.1514157112
et al., Discovery of covalent CDK14 inhibitors with pan-TAIRE family specificity Cell chemical biology June 2020
Cancer, Cell Cycle, Ser/Thr Kinases
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