Recombinant human TTBK1 (1-479) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. T17-11G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
T17-11G-05 | 5 ug | $226 | |
T17-11G-10 | 10 ug | $325 | |
T17-11G-BULK | BULK | Contact Us |
Overview:
TTBK1 or tau-tubulin kinase 1 is a recently discovered brain-specific protein kinase involved in tau phosphorylation at Alzheimer’s disease-related sites. Two single nucleotide polymorphisms have been observed in the TTBK1 gene and these may play an important role in the pathogenesis of sporadic late-onset Alzheimer's disease (1). TTBK1 levels are upregulated in brains of human Alzheimer' disease (AD) patients compared with age-matched non-AD controls (2). Overexpression of TTBK1 in transgenic mice leads to increased phosphorylation-related neurofilament aggregation which results in significant age-dependent memory impairment.
Gene Aliases:
BDTK; RP3-330M21.4
Genbank Number:
References:
1. Yu, N N. et al: Tau-tubulin kinase-1 gene variants are associated with Alzheimer's disease in Han Chinese. Neurosci Lett. 2011 Mar 10;491(1):83-6.
2. Sato, S. et al: Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1. J Neurosci. 2008 Dec 31;28(53):14511-21.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~96 kDa
F. Liachko Nicole et al., CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration Annals of Neurology February 2013 10.1002/ana.23870
F. Liachko Nicole et al., The Tau Tubulin Kinases TTBK1/2 Promote Accumulation of Pathological TDP-43 PLoS Genetics December 2014 10.1371/journal.pgen.1004803
Richard Rubenstein et al., A novel, ultrasensitive assay for tau: potential for assessing traumatic brain injury in tissues and biofluids Journal of Neurotrauma March 2016 10.1089/neu.2014.3548
R Rubenstein et al., A Novel, Ultrasensitive Assay for Tau: Potential for Assessing Traumatic Brain Injury in Tissues and Biofluids Journal of Neurotrauma March 2015 10.1089/neu.2014.3548
Young Leea Jin et al., Celastrol blocks binding of lipopolysaccharides to a Toll-like receptor4/myeloid differentiation factor2 complex in a thiol-dependent manner Journal of Ethnopharmacology August 2015 10.1016/j.jep.2015.06.028
Invasion/Metastasis, Neurobiology, p38 Pathway, Ser/Thr Kinases
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