Recombinant full-length human AURORA A was expressed by baculovirus in Sf9 cells using an N-terminal GST tag.
Catalog No. A28-18G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| A28-18G-05 | 5 ug | $226 | |
| A28-18G-10 | 10 ug | $325 | |
| A28-18G-BULK | BULK | Contact Us |
Overview:
AURORA A belongs to a multigenic family of mitotic serine/threonine kinases which are involved in the control of chromosome segregation. AURORA A is involved in centrosome separation, duplication and maturation as well as in bipolar spindle assembly and stability (1). AURORA A is expressed and active at the highest level during G2-M phase of the cell cycle. Overexpression of AURORA A has been found to be correlated with the grade of various human solid tumours. Ectopic AURORA A overexpression in any culture cell line leads to polyploidy and centrosome amplification (2).
Gene Aliases:
AURKA, AIK, ARK1, AURA, BTAK, STK6, STK7, STK15, AURORA2, MGC34538
Genbank Number:
References:
1. Dutertre, S. et al: On the role of aurora-A in centrosome function. Oncogene. 2002 Sep 9;21(40):6175-83.
2. Katayama, H. et al: The Aurora kinases: role in cell transformation and tumorigenesis. Cancer Metastasis Rev. 2003 Dec;22(4):451-64.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
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Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~72kDa
Jian-Fu Chen et al., Microcephaly disease gene Wdr62 regulates mitotic progression of embryonic neural stem cells and brain size Nature Communications May 2015 10.1038/ncomms4885
C.Thakur Harish et al., The Centrosomal Adaptor TACC3 and the Microtubule Polymerase chTOG Interact via Defined C-terminal Subdomains in an Aurora-A Kinase-independent Manner Journal of Biological Chemistry January 2014 10.1074/jbc.M113.532333
Moa Min et al., Phosphorylation of Xenopus p31comet potentiates mitotic checkpoint exit Cell Cycle April 2015 10.1080/15384101.2015.1033590
Kassardjian Ari et al., The Transcription Factor YY1 Is a Novel Substrate for Aurora B Kinase at G2/M Transition of the Cell Cycle PLoS One November 2012 10.1371/journal.pone.0050645
et al., Acetylshikonin suppressed growth of colorectal tumour tissue and cells by inhibiting the intracellular kinase, T?lymphokine?activated killer cell?originated protein kinase. British Journal of Pharmacology April 2020
et al., Oncoprotein CIP 2A promotes the disassembly of primary cilia and inhibits glycolytic metabolism EMBO Reports May 2018
Cancer, Cell Cycle, Ser/Thr Kinases
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