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Recombinant human PTPN13 (2169-2485) was expressed in E.coli cells using a N-terminal GST tag.
Catalog No. P40-21G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
P40-21G-05 | 5 ug | $226 | |
P40-21G-10 | 10 ug | $325 | |
P40-21G-BULK | BULK | Contact Us |
Overview:
PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN13 is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal-associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif (1). PTPN13 binds to a negative regulatory domain in Fas that inhibits Fas-induced apoptosis (2).
Gene Aliases:
PTP-BAS, PNP1, FAP-1, PTP1E, PTPL1, PTPLE, PTP-BL, DKFZp686J1497
Genbank Number:
References:
1. Saras, J. et al: Cloning and characterization of PTPL1, a protein tyrosine phosphatase with similarities to cytoskeletal-associated proteins. J. Biol. Chem. 269: 24082-24089, 1994.
2. Inazawa, J. et al: PTPN13, a Fas-associated protein tyrosine phosphatase, is located on the long arm of chromosome 4 at band q21.3. Genomics 31: 240-242, 1996.
Specific Activity:
Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~61 kDa
There are no related publications available for this product.
Cancer, Inflammation, Invasion/Metastasis, JAK/STAT Pathway, Metabolic Disorder, Phosphatases, WNT Signaling
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