Full-length recombinant human RBBP5 was expressed in E. coli cells using an N-terminal His tag.
Catalog No. R315-30H
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
R315-30H-20 | 20 ug | $215 | |
R315-30H-50 | 50 ug | $435 | |
R315-30H-BULK | BULK | Contact Us |
Overview:
Retinoblastoma-binding protein 5 (RBBP5) is believed to play a crucial role in the differentiation potential, particularly along the neural lineage in embryonic stem (ES) cells, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity). As part of the MLL1/MLL complex, involved in mono-, di- and tri-methylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.
Gene Aliases:
RBQ3; SWD1
Genbank Number:
References:
1. Thttp://www.uniprot.org/uniprot/Q15291
2. Patel A, et al: On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex. J Biol Chem. 2009; 284(36):24242-56.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~72 kDa
Cancer, Cell Cycle, Neurobiology
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