Overview:

Catechol O-methyltransferase (COMT) is a major catabolic regulator of synaptic catecholamine neurotransmitters and it catalyzes the transfer of a methyl group to catecholamines and degrades dopamine, norepinephrine and epinephrine. The two forms of COMT (soluble COMT [S-COMT] and membrane-bound COMT [MB-COMT]) encoded by a single gene located on 22q11.2 have been identified. Activation of COMT affects the biological half-lives of certain neuroactive drugs.

Gene Aliases:

HEL-S-98n

Genbank Number:

NM_000754

References:

1. Pivac N, et al: The association between catechol-O-methyl-transferase Val108/158Met polymorphism and suicide. Genes Brain Behav. 2011;10(5):565–9

2. Wardle MC, et al: Does COMT genotype influence the effects of d-amphetamine on executive functioning? Genes Brain Behav. 2013;12(1):13–20.

3. http://www.uniprot.org/uniprot/P21964