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CK1 delta, Active

Full length recombinant human CK1 delta was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. C65-10G


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Catalog No. Pack Size Price (USD)
C65-10G-05 5 ug $226
C65-10G-10 10 ug $325
C65-10G-BULK BULK Contact Us  


Overview:

CK1δ is a member of the CK1 family of serine/threonine protein kinases which play an important role in diverse cell processes, including DNA replication and repair. CK1δ is a regulator of Yes-associated protein (YAP) transcription coactivator which is a key regulator of organ size and a candidate human oncogene. CK1δ is activated by CCK2R and this then phosphorylates PKD2 at Ser244. Phosphorylation of PKD2 leads to its nuclear accumulation and efficient phosphorylation of nuclear PKD2 substrates in human gastric cancer cells (1). CKIδ can phosphorylate in vitro deoxycytidine kinase (dCK) which is a key enzyme in the salvage of deoxynucleosides. Phosphorylation of dCK by CKIδ in vitro correlates with increased activity of this enzyme (2).


Gene Aliases:

CSNK1D, HCKID, CK1D


Genbank Number:


References:


1. von Blume J. et al: Phosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2. EMBO J. 2007 Nov 14;26(22):4619-33.

2. Smal, C. et al: Casein kinase 1delta activates human recombinant deoxycytidine kinase by Ser-74 phosphorylation, but is not involved in the in vivo regulation of its activity. Arch Biochem Biophys. 2010 Oct 1;502(1):44-52.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~72 kDa



Product Datasheets



RESEARCH AREAS

Cancer, Inflammation, Neurobiology, NfkB Pathway, Ser/Thr Kinases, WNT Signaling


RELATED PRODUCTS


  CK1 alpha 1, Active, C64-10G

  CK1 epsilon, Active, C66-10G

  CK1 gamma 2, Active, C68-10BG

  CK1 gamma 3, Active, C68-10CG


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