Recombinant human KAT6B (MYST4) (657-1069; contains the catalytic domain) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. K315-381BG
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| K315-381BG-05 | 5 ug | $259 | |
| K315-381BG-10 | 10 ug | $380 | |
| K315-381BG-BULK | BULK | Contact Us |
Overview:
KAT6B is the catalytic subunit of the histone acetyltransferase (HAT) elongator complex, which is ubiquitously expressed in adult human tissues. KAT6B is a 1,781aa-residue protein that contains a strong transcriptional repression domain at its N terminus and a highly potent activation domain at its C terminus (1). These domains of KAT6B may be involved in both positive and negative regulation of transcription and also involved in cerebral cortex development. KAT6B is important for cellular aging, proliferation, positive and negative transcriptional regulation and DNA damage repair (2).
Gene Aliases:
MYST4; DKFZp313G1618; FLJ90335; KIAA0383; MORF; MOZ2; qkf; querkopf
Genbank Number:
References:
1. Champagne, N. et.al: Identification of a human histone acetyltransferase related to monocytic leukemia zinc finger protein. J. Biol. Chem. 274: 28528-28536, 1999.
2. Pena AN, et.al: The role of the MORF/MRG family of genes in cell growth, differentiation, DNA repair, and thereby aging. DOI: 10.1196/annals: 299–305, April 2007.
Specific Activity:
Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.
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Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~76 kDa
Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, PKA/PKC Pathway
Acetyltransferase Dilution Buffer, A21-09
Acetyltransferase Assay Buffer, A01-09
Histone H4 Peptide (1-21), H13-58
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