Recombinant human fusion protein TPM3 (1-258)-TRKA (399-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. N16-19DG
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| N16-19DG-05 | 5 ug | $259 | |
| N16-19DG-10 | 10 ug | $380 | |
| N16-19DG-BULK | BULK | Contact Us |
Overview:
TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family which is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TRKA has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermoregulation via sweating in humans (1). The oncogenic rearrangement of 5′TPM3-3′NTRK1 fusion gene has been found in papillary thyroid carcinomas (2).
Gene Aliases:
TPM3: CAPM1; CFTD; hscp30; NEM1; TM-5; TM3; TM30; TM30nm; TM5; TPMsk3; OK/SW-cl.5
TRKA: NTRK1, MTC, TRK, p140-TrkA
References:
1. Smeyne, R. J. et.al: Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. Nature 368: 246-249, 1994.
2. Marta G. B. et.al: A Sequence Analysis of the Genomic Regions Involved in the Rearrangements between TPM3 and NTRK1 Genes Producing TRK Oncogenes in Papillary Thyroid Carcinomas. Genomics, Volume 28, Issue 1, 1 July 1995, Pages 15–24
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
|
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
|
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~105 kDa
Cancer
Kinase Dilution Buffer IV, K24-09
Kinase Assay Buffer II, K02-09
ATP Stock Solution, A50-09
Poly (4:1 Glu, Tyr) Peptide, P61-58
STAY CONNECTED
Fax: 1-604-232-4601
Toll Free: 1-866-954-6273
info@signalchem.com