Overview:

TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family which is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TRKA has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermoregulation via sweating in humans (1). As one of the thyroid TRK oncogenes, TRK-T1 is created by an intrachromosomal rearrangement that juxtaposes the 5' end of the TPR gene to the TRK tyrosine kinase domain and shows frequent activation of the TRK in human papillary thyroid carcinoma (2).

Gene Aliases:

TPR: (None)
TRKA: NTRK1, MTC, TRK, p140-TrkA

Genbank Number:

NM_003292
NM_002529

References:

1. Smeyne, R. J. et.al: Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. Nature 368: 246-249, 1994.

2. Greco A. et.al: TRK-T1 is a novel oncogene formed by the fusion of TPR and TRK genes in human papillary thyroid carcinomas. Oncogene. 1992 Feb;7(2):237-42.