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TPM3-ROS1, Active

Recombinant human fusion protein TPM3 (1-258)-ROS1 (1881-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. R14-19CG


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Catalog No. Pack Size Price (USD)
R14-19CG-05 5 ug $259
R14-19CG-10 10 ug $380
R14-19CG-BULK BULK Contact Us  


Overview:

TPM3 is a member of the tropomyosin family of actin-binding proteins which are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in TPM3 gene result in autosomal dominant nemaline myopathy and other muscle disorders (1). TPM3 gene locus is involved in translocations with other loci including c-ros oncogene 1 (ROS1) which result in the formation of the TPM3-ROS1 fusion protein that act as an oncogene. TPM3-ROS1 fusion gene product has been detected in lung adenocarcinoma is higher in lung adenocarcinoma with wild-type EGFR (2).


Gene Aliases:

TPM3: CAPM1; CFTD; hscp30; NEM1; OK/SW-cl.5; TM-5; TM3; TM30; TM30nm; TM5; TPMsk3; TRK
ROS1: c-ros-1; MCF3; ROS


Genbank Number:


References:


1. Lawlor, M W. et al: Mutations of tropomyosin 3 (TPM3) are common and associated with type 1 myofiber hypotrophy in ongenital fiber type disproportion. Hum Mutat. 2010 Feb;31(2):176-83.

2. Zhao C. et al: Detecting ALK, ROS1 and RET Fusion Genes in Cell Block Samples. Transl Oncol. 2014 Jun 17;7 (3):363-7.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

108 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer



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