TPM3 is a member of the tropomyosin family of actin-binding proteins which are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in TPM3 gene result in autosomal dominant nemaline myopathy and other muscle disorders (1). TPM3 gene locus is involved in translocations with other loci including c-ros oncogene 1 (ROS1) which result in the formation of the TPM3-ROS1 fusion protein that act as an oncogene. TPM3-ROS1 fusion gene product has been detected in lung adenocarcinoma is higher in lung adenocarcinoma with wild-type EGFR (2).
TPM3: CAPM1; CFTD; hscp30; NEM1; OK/SW-cl.5; TM-5; TM3; TM30; TM30nm; TM5; TPMsk3; TRK
ROS1: c-ros-1; MCF3; ROS
1. Lawlor, M W. et al: Mutations of tropomyosin 3 (TPM3) are common and associated with type 1 myofiber hypotrophy in ongenital fiber type disproportion. Hum Mutat. 2010 Feb;31(2):176-83.
2. Zhao C. et al: Detecting ALK, ROS1 and RET Fusion Genes in Cell Block Samples. Transl Oncol. 2014 Jun 17;7 (3):363-7.
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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