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JAK1 (R724H), Active

Recombinant human JAK1 (R724H) (438-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. J01-12BG


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Catalog No. Pack Size Price (USD)
J01-12BG-05 5 ug $259
J01-12BG-10 10 ug $380
J01-12BG-BULK BULK Contact Us  


Overview:

JAK1 is a member of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. JAK1 bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein that is involved in the interferon-alpha/beta and -gamma signal transduction pathways (1). JAK1 plays an essential and nonredundant role in promoting biologic responses induced by a select subset of cytokine receptors, including those in which JAK utilization is thought to be nonspecific(2).


Gene Aliases:

JAK1A, JAK1B


Genbank Number:


References:


1. Muller, M.et.al: The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction. Nature 366: 129-135, 1993.

2. Rodig, S. J.et.al: Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses. Cell 93: 373-383, 1998.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~105 kDa



Product Datasheets



RESEARCH AREAS

Cancer, Cardiovascular Disease, Cytoplasmic Tyrosine Kinases, Inflammation, JAK/STAT Pathway


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