Recombinant full-length human BTK (T474I) was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Catalog No. B10-12HH
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
B10-12HH-05 | 5 ug | $226 | |
B10-12HH-10 | 10 ug | $325 | |
B10-12HH-BULK | BULK | Contact Us |
Overview:
BTK (also known as Bruton tyrosine kinase) plays a crucial role in B-lymphocyte differentiation and activation. BTK interacts with SRC homology 3 domains of FYN, LYN and HCK that are activated upon stimulation of B- and T-cell receptors (1). Defects in the BTK gene cause Agammaglobulinemia, an X-linked immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. The unique role of BTK makes it a desirable target for potential anti-cancer, anti-inflammatory and anti-viral agents as well as other treatments (2).
Gene Aliases:
AT; ATK; BPK; XLA; IMD1; AGMX1; PSCTK
Genbank Number:
References:
1. Cheng, G. et al: Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction. Proc. Nat. Acad. Sci. 91: 8152-8155, 1994.
2. Vassilev, A O. et al: Therapeutic potential of inhibiting Bruton's tyrosine kinase, (BTK).Curr Pharm Des. 2004;10(15):1757-66.
Specific Activity:
Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~75 kDa
There are no related publications available for this product.
Cancer, Cytoplasmic Tyrosine Kinases, Inflammation, NfkB Pathway
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