CK2α is a serine-threonine protein kinase whose targets include many critical regulators of cellular growth. It is highly expressed in a lymphopro-liferative disease of cattle and in many human cancers. Overexpression of the CK2 catalytic subunit in lymphocytes of transgenic mice leads to T cell lymphoma (1). The highest CK2α1 activity is found in mouse testicles and brain, followed by spleen, liver, lung, kidney and heart (2).
CKII; CK2A1; CKIIα; CSNK2A1
1. Rifkin, IR. et al: Acceleration of lymphoproliferative and autoimmune disease by transgenic protein kinase CK2 alpha. J Immunol. 1998 Nov 15;161(10):5164-70.
2. Guerra B. et al: Protein kinase CK2: evidence for a protein kinase CK2beta subunit fraction, devoid of the catalytic CK2alpha subunit, in mouse brain and testicles. FEBS Lett. 1999 Dec 3;462(3):353-7.
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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Cancer, Inflammation, Neurobiology, NfkB Pathway, Ser/Thr Kinases, WNT Signaling