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CK2 alpha 1, Active

Recombinant full-length human CK2alpha1 was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Catalog No. C70-10G


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Catalog No. Pack Size Price (USD)
C70-10G-05 5 ug $226
C70-10G-10 10 ug $325
C70-10G-BULK BULK Contact Us  


Overview:

CK2α is a serine-threonine protein kinase whose targets include many critical regulators of cellular growth. It is highly expressed in a lymphopro-liferative disease of cattle and in many human cancers. Overexpression of the CK2 catalytic subunit in lymphocytes of transgenic mice leads to T cell lymphoma (1). The highest CK2α1 activity is found in mouse testicles and brain, followed by spleen, liver, lung, kidney and heart (2).


Gene Aliases:

CKII; CK2A1; CKIIα; CSNK2A1


Genbank Number:


References:


1. Rifkin, IR. et al: Acceleration of lymphoproliferative and autoimmune disease by transgenic protein kinase CK2 alpha. J Immunol. 1998 Nov 15;161(10):5164-70.

2. Guerra B. et al: Protein kinase CK2: evidence for a protein kinase CK2beta subunit fraction, devoid of the catalytic CK2alpha subunit, in mouse brain and testicles. FEBS Lett. 1999 Dec 3;462(3):353-7.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~70 kDa



Product Datasheets



RESEARCH AREAS

Cancer, Inflammation, Neurobiology, NfkB Pathway, Ser/Thr Kinases, WNT Signaling


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