Recombinant full-length human CK2alpha1 was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Catalog No. C70-10G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
C70-10G-05 | 5 ug | $226 | |
C70-10G-10 | 10 ug | $325 | |
C70-10G-BULK | BULK | Contact Us |
Overview:
CK2α is a serine-threonine protein kinase whose targets include many critical regulators of cellular growth. It is highly expressed in a lymphopro-liferative disease of cattle and in many human cancers. Overexpression of the CK2 catalytic subunit in lymphocytes of transgenic mice leads to T cell lymphoma (1). The highest CK2α1 activity is found in mouse testicles and brain, followed by spleen, liver, lung, kidney and heart (2).
Gene Aliases:
CKII; CK2A1; CKIIα; CSNK2A1
Genbank Number:
References:
1. Rifkin, IR. et al: Acceleration of lymphoproliferative and autoimmune disease by transgenic protein kinase CK2 alpha. J Immunol. 1998 Nov 15;161(10):5164-70.
2. Guerra B. et al: Protein kinase CK2: evidence for a protein kinase CK2beta subunit fraction, devoid of the catalytic CK2alpha subunit, in mouse brain and testicles. FEBS Lett. 1999 Dec 3;462(3):353-7.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~70 kDa
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I. Dobrikov Mikhail et al., Dynamic Regulation of the Translation Initiation Helicase Complex by Mitogenic Signal Transduction to Eukaryotic Translation Initiation Factor 4G Molecular and Cellular Biology March 2013 10.1128/MCB.01441-12
Rimana Sarah et al., Phosphorylation of the Transcription Factor YY1 by CK2α Prevents Cleavage by Caspase 7 during Apoptosis Molecular and Cellular Biology February 2012 10.1128/MCB.06466-11
Gagne Philippe Jean et al., Proteomic Investigation of Phosphorylation Sites in Poly(ADP-ribose) Polymerase-1 and Poly(ADP-ribose) Glycohydrolase Journal of Proteome Research February 2009 10.1021/pr800810n
Cancer, Inflammation, Neurobiology, NfkB Pathway, Ser/Thr Kinases, WNT Signaling
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