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c-KIT (Y823D), Active

Recombinant human c-KIT (Y823D) (544-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. K06-12GG


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Catalog No. Pack Size Price (USD)
K06-12GG-05 5 ug $226
K06-12GG-10 10 ug $325
K06-12GG-BULK BULK Contact Us  


Overview:

c-KIT (Y823D) encodes the ligand-binding chain (alpha) of the gamma interferon receptor which is a heterodimer of IFNGR1 and IFNGR2. c-KIT (Y823D) is a regulator of hematopoietic stem cells during homeostasis and under conditions of infectious stress. A genetic variation in c-KIT (Y823D) is associated with susceptibility to Helicobacter pylori infection. In addition, defects in c-KIT (Y823D) are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection (1). c-KIT (Y823D is also associated with the clinical outcome of HBV infection in Chinese adults (2).


Gene Aliases:

PBT, SCFR, CD119


Genbank Number:


References:


1. Baldridge, M. T. et.al: Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection. Nature 465: 793-797, 2010.

2. Zhou, J. et.al: A regulatory polymorphism in interferon-gamma receptor 1 promoter is associated with the susceptibility to chronic hepatitis B virus infection. Immunogenetics 61: 423-430, 2009.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~73 kDa



RESEARCH AREAS

Cancer, Inflammation, Neurobiology, Receptor Tyrosine Kinases


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