Recombinant full-length human NEK2 was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Catalog No. N03-10G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
N03-10G-05 | 5 ug | $226 | |
N03-10G-10 | 10 ug | $325 | |
N03-10G-BULK | BULK | Contact Us |
Overview:
NEK 2 is closely related in its catalytic domain to the serine/threonine protein kinase NIMA of Aspergillus nidulans that is required for entry into mitosis and may function in parallel to the universal mitotic inducer p34cdc2. Like NIMA, the NEK2 protein is almost undetectable during G1 but accumulated progressively throughout S, reaching maximal levels in late G2 (1). NEK2 is shown to be expressed most abundantly in the testis of the adult tissues examined being localized to the nucleus (2).
Gene Aliases:
NLK1; HsPK21; NEK2A
Genbank Number:
References:
1. Schultz, SJ. et al: A. Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans. Cell Growth Differ. 1994 Jun;5(6):625-35.
2. Fry, AM. et al: Substrate specificity and cell cycle regulation of the Nek2 protein kinase, a potential human homolog of the mitotic regulator NIMA of Aspergillus nidulans. J Biol Chem. 1995 May 26; 270(21):12899-905.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~76 kDa
There are no related publications available for this product.
Cancer, Cell Cycle, Ser/Thr Kinases
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