Recombinant full-length human PKCgamma was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Catalog No. P66-10G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| P66-10G-05 | 5 ug | $160 | |
| P66-10G-10 | 10 ug | $226 | |
| P66-10G-BULK | BULK | Contact Us |
Overview:
PKCγ is a member of the protein kinase C (PKC) family of serine- and threonine-specific protein kinases that can phosphorylate a wide variety of protein targets known to be involved in diverse cellular signaling pathways. In the brain, PKCγ is translocated to cell membranes during ischemia and is rapidly removed or degraded during the second otherwise lethal ischemic insult in preconditioned brains. This suggest that ischemic preconditioning enhances downregulation of cell signaling mediated by PKCγ and may thereby provide neuroprotection (1).
Gene Aliases:
PKCC; PKCG; SCA14; MGC57564; PKC-gamma; PRKCG
Genbank Number:
References:
1. Shamloo, M. et al: Rapid decline in protein kinase Cgamma levels in the synaptosomal fraction of rat hippocampus after ischemic preconditioning. Neuroreport. 1999 Apr 6;10(5):931-5.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
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Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~105 kDa
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J. Coultrap Steven et al., Improving a Natural CaMKII Inhibitor by Random and Rational Design PLoS One October 2011 10.1371/journal.pone.0025245
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Apoptosis/Autophagy, Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, NfkB Pathway, PKA/PKC Pathway, Ser/Thr Kinases
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