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IKK beta, Active

Full-length recombinant human IKKbeta was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. I03-18G

Catalog No. Pack Size Price (USD)
I03-18G-05 5 ug $259
I03-18G-10 10 ug $380
I03-18G-BULK BULK Contact Us  


IKKbeta is a serine/threonine protein kinase that phosphorylates the I-kappa-B protein which is an inhibitor of the transcription factor NF-kappa-B complex. Phosphorylation of I-kappa-B protein triggers the degradation of the inhibitor via the ubiquitination pathway, thereby activating NF-kappa-B complex. The activity of IKKbeta is stimulated by TNF and IL1 and IKKbeta forms a heterodimer that interacts with NIK (1). Overexpression of catalytically inactive IKKbeta blocks cytokine-induced NF-kappa-B activation. Aspirin and sodium salicylate can specifically inhibit IKKbeta activity in vitro and in vivo by binding to IKKbeta to reduce ATP binding (2).

Gene Aliases:

IKK2, IKBKB, IKKB, NFKBIKB, FLJ40509, IKK-beta, MGC131801

Genbank Number:


1. Woronicz, J D. et al: IkappaB kinase-beta: NF-kappa-B activation and complex formation with IkappaB kinase-alpha and NIK. Science 278: 866-869, 1997.

2. Yin, M.-J. et al: The anti-inflammatory agents aspirin and salicylate inhibit the activity of I-kappa-B kinase-beta. Nature 396: 77-80, 1998.

Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Molecular Weight:

~115 kDa

Product Datasheets


AKT/PKB Pathway, Apoptosis/Autophagy, Inflammation, p38 Pathway


  Kinase Dilution Buffer III, K23-09

  Kinase Assay Buffer I, K01-09

  ATP Stock Solution, A50-09

  IKKtide, I33-58



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