H11 or heat shock 22kDa protein 8 belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of H11 is induced by estrogen in estrogen receptor-positive breast cancer cells, and H11 also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. H11 is involved in regulation of cell proliferation, apoptosis, and carcinogenesis (1). H11 also causes motor neuron-specific neurite degeneration (2).
HSP22; CRYAC; CMT2L; DHMN2; E2IG1; HSPB8; HMN2; HMN2A; PP1629
1. Benndorf, R.et.al: Shocking degeneration. Nature Genet. 36: 547-548, 2004.
2. Irobi, J.et.al: Mutant HSPB8 causes motor neuron-specific neurite degeneration. Hum. Molec. Genet. 19: 3254-3265, 2010.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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AKT/PKB Pathway, Apoptosis/Autophagy, Cardiovascular Disease, Cell Cycle, Metabolic Disorder, NfkB Pathway