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H11 (HSP22) Protein

Full-length recombinant human H11 (HSP22) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. H09-34G


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Catalog No. Pack Size Price (USD)
H09-34G-20 20 ug $215
H09-34G-50 50 ug $435
H09-34G-BULK BULK Contact Us  


Overview:

H11 or heat shock 22kDa protein 8 belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of H11 is induced by estrogen in estrogen receptor-positive breast cancer cells, and H11 also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. H11 is involved in regulation of cell proliferation, apoptosis, and carcinogenesis (1). H11 also causes motor neuron-specific neurite degeneration (2).


Gene Aliases:

HSP22; CRYAC; CMT2L; DHMN2; E2IG1; HSPB8; HMN2; HMN2A; PP1629


Genbank Number:


References:


1. Benndorf, R.et.al: Shocking degeneration. Nature Genet. 36: 547-548, 2004.

2. Irobi, J.et.al: Mutant HSPB8 causes motor neuron-specific neurite degeneration. Hum. Molec. Genet. 19: 3254-3265, 2010.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~50 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

AKT/PKB Pathway, Apoptosis/Autophagy, Cardiovascular Disease, Cell Cycle, Metabolic Disorder, NfkB Pathway


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