SRC kinase inhibitor
Catalog No. S19-901
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| S19-901-05 | 5 mg | $75 | |
| S19-901-25 | 25 mg | $300 | |
| S19-901-BULK | BULK | Contact Us |
Overview:
Potent, competitive dual site (ATP- and substrate-binding domains) Src and Lck inhibitor (IC50 = 44 and 88 nM respectively). Also inhibits VEGFR2 and c-fms at higher concentrations (IC50 = 0.32 and 30 uM respectively).
References:
1. Tian et al. Biochem. 2001 40:7084
2. J Bain et al. Biochem. J. 2007 408:297
CAS Registry Number:
179248-59-0
Molecular Formula:
C22H19N3O3
Appearance:
White solid
Melting Point:
243-245oC
Molecular Weight:
373.4
Purity:
≥98% (TLC; 5% CH3OH in CH2Cl2; Rf=0.43); NMR (Conforms)
Solubilization:
Soluble in DMSO (15 mg/ml); Ethanol (nil)
Aliases:
6,7-Dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine
Storage and Stability:
Store desiccated as supplied at ambient temperature for up to 3 years. Store solutions at -20oC for up to 3 months.
Molecular Structure:
|
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Angiogenesis, Apoptosis/Autophagy, Cancer, Cytoplasmic Tyrosine Kinases, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, JAK/STAT Pathway
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