ASK3 (MAP3K15) is a member of the mitogen-activated protein kinase (MAPK) family which functions in a protein kinase signal transduction cascade, where an activated MAPK kinase kinase (MAP3K) phosphorylates and activates a specific MAPK kinase (MAP2K), which then activates a specific MAPK. ASK3 plays an essential role in apoptotic cell death triggered by cellular stresses (1). ASK3 is also functions in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis (2).
MAP3K15; ASK3; bA723P2.3
1. Hartz, P. A.et.al: Personal Communication. Baltimore, Md. 7/26/2010.
2. Kaji, T. et.al: ASK3, a novel member of the apoptosis signal-regulating kinase family, is essential for stress-induced cell death in HeLa cells.
Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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Apoptosis/Autophagy, Cancer, Cellular Stress, JNK/SAPK Pathway, p38 Pathway, Ser/Thr Kinases