HUNK or hormonally up-regulated Neu-associated kinase is a member of the mitogen-activated protein kinase which is essential for mammary tumor metastasis (1). Hunk deletion in mice did not alter viability, fertility, longevity, or propensity to develop tumors and it is also dispensable for murine development (2).
1. Gardner, H. P.et.al: Cloning and characterization of Hunk, a novel mammalian SNF1-related protein kinase. Genomics 63: 46-59, 2000.
2. Wertheim, G. B. W. et.al: The Snf1-related kinase, Hunk, is essential for mammary tumor metastasis. Proc. Nat. Acad. Sci. 106: 15855-15860, 2009.
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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Cancer, Ser/Thr Kinases