DYRK1 A or dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A is a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family which contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. DYRK1A participates in various cellular processes. DYRK1A is a highly conserved gene located in the so-called Down Syndrome critical region (DSCR) on part of chromosome 21 that is responsible for the majority of phenotypic features in Down syndrome (1). DYRK1A plays a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. DYRK1A is also contributing to early onset of Alzheimer disease (2).
1. van Bon, B. et al: Intragenic deletion in DYRK1A leads to mental retardation and primary microcephaly. Clin. Genet. 79: 296-299, 2011.
2. Ryoo, S. R. et al: DYRK1A-mediated hyperphosphorylation of tau: a functional link between Down syndrome and Alzheimer disease. J. Biol. Chem. 282: 34850-34857, 2007.
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
AKT/PKB Pathway, AKT/PKB Pathway, Apoptosis/Autophagy, Apoptosis/Autophagy, Cancer, Cancer, Cardiovascular Disease, Cardiovascular Disease, Inflammation, Inflammation, Invasion/Metastasis, Invasion/Metastasis, Metabolic Disorder, Metabolic Disorder, Neurobiology, Neurobiology, NfkB Pathway, NfkB Pathway, Ser/Thr Kinases, Ser/Thr Kinases, WNT Signaling, WNT Signaling