CLK family Inhibitor
Catalog No. C57-901
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| C57-901-05 | 5 mg | $120 | |
| C57-901-25 | 25 mg | $450 | |
| C57-901-BULK | BULK | Contact Us |
Overview:
Potent, ATP-competitive inhibitor of Clk-family kinases (IC50s = 15, 20 and 200 nM for mClk4, 1 and 2 respectively and >10 µM for mClk3)1. Also inhibits DYRK1A/B (IC50s = 24 and 34 nM respectively)2.
References:
1. J Bain M Muraki et al. J. Biol. Chem. 2004 279:24246
2. A Foucourt et al. Molecules 2014 19:15411
3. S A Nishida et al. Nat. Commun. 2011 2:308
CAS Registry Number:
719277-26-6
Molecular Formula:
C13H15NO2S
Appearance:
light yellow powder
Molecular Weight:
249.33
Purity:
>98% (HPLC); NMR (Conforms)
Solubilization:
May be dissolved in DMSO (20 mg/ml); or ethanol (15 mg/ml)
Aliases:
(Z)-1-(3-Ethyl-5-methoxy-2,3-dihydrobenzothiazol-2-ylidene)propan-2-one
Storage and Stability:
Store desiccated as supplied at 4oC temperature for up to 2 years. Store solutions at -20oC for up to 2 months.
Molecular Structure:
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There are no related publications available for this product.
Cancer, Cardiovascular Disease, Cell Cycle, Ser/Thr Kinases
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