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AKT2, Active

Recombinant full-length human AKT2 was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Catalog No. A17-10G


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Catalog No. Pack Size Price (USD)
A17-10G-05 5 ug $226
A17-10G-10 10 ug $325
A17-10G-BULK BULK Contact Us  


Overview:

AKT2 or Protein Kinase B β (PKBβ) is a serine/threonine kinase that is a member of the AKT family. AKT2 like the other AKT members is activated in cells in response to diverse stimuli such as hormones, growth factors and extracellular matrix components and is involved in glucose metabolism, transcription, survival, cell proliferation, angiogenesis, and cell motility. The PI3K generates phosphatidylinositol-3,4,5-trisphosphate (PIP3), a lipid second messenger essential for the translocation of AKT2 to the plasma membrane where it is phosphorylated and activated by phosphoinositide-dependent kinase-1 (PDK-1).


Gene Aliases:

PRKBB; PKBBETA; RAC-BETA


Genbank Number:


References:


1. Coffer, PJ. et al: Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem J. 1998 Oct 1; 335 ( Pt 1):1-13.

2. Anderson, KE. et al: Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B. Curr Biol. 1998 Jun 4;8(12): 684-91.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~85 kDa



Product Datasheets



 AS Brown et al., Identification and characterization of an hnRNP E1 translational silencing motif. Nucleir Acid Research July 2016 10.1093/nar/gkw241

 Liu X et al., Targeted therapy of the AKT kinase inhibits esophageal squamous cell carcinoma growth in vitro and in vivo International journal of cancer March 2019 10.1002/ijc.32285

 L. Parker Benjamin et al., Targeted phosphoproteomics of insulin signaling using data-independent acquisition mass spectrometry Science Signaling June 2015 10.1126/scisignal.aaa3139

 Li D et al., Resveratrol suppresses colon cancer growth by targeting the AKT/STAT3 signaling pathway Int J Mol Med November 2018 10.3892/ijmm.2018.3969

 Zenga in et al., Lanthionine synthetase C-like protein 2 (LanCL2) is a novel regulator of Akt Molecular Biology of the Cell September 2014 10.1091/mbc.E14-01-0004

 Bavelloni Alberto et al., Prohibitin 2 represents a novel nuclear AKT substrate during all-trans retinoic acid-induced differentiation of acute promyelocytic leukemia cells FASEB Journal February 2014 10.1096/fj.13-244368

 Pecorari Luisa et al., Elongation Factor 1 alpha interacts with phospho-Akt in breast cancer cells and regulates their proliferation, survival and motility Molecular Cancer August 2009 10.1186/1476-4598-8-58

 Treebak Jonas et al., Identification of a novel phosphorylation site on TBC1D4 regulated by AMP-activated protein kinase in skeletal muscle American Journal of Physiology - Cell Physiology November 2009 10.1152/ajpcell.00297.2009

 Zhang Mingpeng et al., Poly r (C) binding protein (PCBP) 1 is a negative regulator of thyroid carcinoma AM J Transl Res August 2016

 M Zhang et al., Poly r(C) binding protein (PCBP) 1 is a negative regulator of thyroid carcinoma. American Journal of Translational Research August 2016

 Brown AS et al., IDENTIFICATION OF A PHOSPHO-HNRNP E1 NUCLEIC ACID CONSENSUS SEQUENCE MEDIATING EPITHELIAL TO MESENCHYMAL TRANSITION Thesis January 2015


RESEARCH AREAS

AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, WNT Signaling


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