Multi-kinase inhibitor (Including KDR-Tie2)
Catalog No. K01-900
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| K01-900-05 | 5 mg | $90 | |
| K01-900-25 | 25 mg | $360 | |
| K01-900-BULK | BULK | Contact Us |
Overview:
A multi-kinase inhibitor related to sorafenib1. Inhibits c-Raf, B-Raf, VEGFR1, VEGFR2, VEGFR3, Tie2, PDGFRβ; FGFR1, c-Kit, and RET with IC50s=2.5, 28, 13, 4.2, 46, 311, 22, 202, 7 and 1.5 nM respectively1-2
References:
1. SM Wilhelm et al. Int. J. Cancer 2011 129:245
2. JCM Uitdehaag et al. PLoS One 2014 9(3):e92146
CAS Registry Number:
755037-03-7
Molecular Formula:
C21H15ClF4N4O3
Appearance:
Off-White powder
Molecular Weight:
482.80
Purity:
>98% (HPLC,TLC); NMR (conforms)
Solubilization:
May be dissolved in DMSO (50 mg/ml)
Aliases:
4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide; BAY 73-4506
Storage and Stability:
Store desiccated as supplied at -20oC for up to 2 year. Store solutions at -20oC for up to 3 months.
Molecular Structure:
|
There are no related publications available for this product.
AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Inflammation, p38 Pathway, Receptor Tyrosine Kinases
STAY CONNECTED
Fax: 1-604-232-4601
KDR, Active, K01-11G
Toll Free: 1-866-954-6273
info@signalchem.com