The Cardiac Troponin I - interacting kinase (TNNI3K) is a serine/threonine-protein kinase, that is a member of the MAPKKK family (1). As a cardiac-specific kinase, it contains Ankyrin repeat, protein kinase, and serine-rich domains and highly expressed in the cardiomyocytes (1). Overexpression of TNNI3K has been shown to increase the progression of cardiomyopathy in mice through the Tyr and Ser/Thr kinase activity (2). The TNNI3K mutation has been involved in a familial syndrome of conduction system disease and dilated cardiomyopathy by causing the aggregation of this protein (3).
1. Y. Zhao, et al: Cloning and characterization of a novel cardiac-specific kinase that interacts specifically with cardiac troponin I. J Mol Med. 81: 297–304, 2003.
2. H. Tang, et al: Overexpression of TNNI3K, a cardiac specific MAPKKK, promotes cardiac dysfunction. J Mol Cell Cardiol. 54: 101-111, 2013.
3. J. L. Theis, et al: TNNI3K mutation in familial syndrome of conduction system disease, atrial tachyarrhythmia and dilated cardiomyopathy. Human Molecular Genetics. 23: 5793-5804, 2014.
Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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