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TNNI3K, Active

Recombinant human TNNI3K (300-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. T13-11G


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Catalog No. Pack Size Price (USD)
T13-11G-05 5 ug $226
T13-11G-10 10 ug $325
T13-11G-BULK BULK Contact Us  


Overview:

The Cardiac Troponin I - interacting kinase (TNNI3K) is a serine/threonine-protein kinase, that is a member of the MAPKKK family (1). As a cardiac-specific kinase, it contains Ankyrin repeat, protein kinase, and serine-rich domains and highly expressed in the cardiomyocytes (1). Overexpression of TNNI3K has been shown to increase the progression of cardiomyopathy in mice through the Tyr and Ser/Thr kinase activity (2). The TNNI3K mutation has been involved in a familial syndrome of conduction system disease and dilated cardiomyopathy by causing the aggregation of this protein (3).


Gene Aliases:

CARK, CCDD


Genbank Number:


References:


1. Y. Zhao, et al: Cloning and characterization of a novel cardiac-specific kinase that interacts specifically with cardiac troponin I. J Mol Med. 81: 297–304, 2003.

2. H. Tang, et al: Overexpression of TNNI3K, a cardiac specific MAPKKK, promotes cardiac dysfunction. J Mol Cell Cardiol. 54: 101-111, 2013.

3. J. L. Theis, et al: TNNI3K mutation in familial syndrome of conduction system disease, atrial tachyarrhythmia and dilated cardiomyopathy. Human Molecular Genetics. 23: 5793-5804, 2014.


Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~87 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cardiovascular Disease


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