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TEC, Active

Full-length recombinant human TEC was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. T03-10G


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Catalog No. Pack Size Price (USD)
T03-10G-05 5 ug $226
T03-10G-10 10 ug $325
T03-10G-BULK BULK Contact Us  


Overview:

TEC is a member of the Tec family of non-receptor protein-tyrosine kinases that are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. TEC is an integral component of T cell signaling and has a distinct role in T cell activation. Defects in TEC may be associated with myelodysplastic syndrome. TEC plays a crucial role in regulating FGF2 secretion under various physiological conditions (1) and it inhibits CD25 expression in human T-lymphocyte (2).


Gene Aliases:

PSCTK4, MGC126760, MGC126762


Genbank Number:


References:


1. Ebert,A.D.et.al: Tec-kinase-mediated phosphorylation of fibroblast growth factor 2 is essential for unconventional secretion. Traffic 11 (6), 813-826 (2010).

2. Susaki,K.et.al: TEC protein tyrosine kinase inhibits CD25 expression in human T-lymphocytes. Immunol. Lett. 127 (2), 135-142 (2010)


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~103 kDa



There are no related publications available for this product.


RESEARCH AREAS

Angiogenesis, Cancer, Cardiovascular Disease, Inflammation, Neurobiology, Receptor Tyrosine Kinases


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