Overview:

CaMKPase is a member of the PP2C family of Ser/Thr protein phosphatases that dephosphorylate and regulate the multifunctional Ca2+/calmodulin-dependent protein kinases (CaMKs) (1). The multifunctional CaMKs mediate cellular responses induced by increases in second messenger Ca2+ and have been implicated in the control of synaptic transmission, gene transcription, cell growth and contraction of cardiac and smooth muscles (2). Overexpression of CaMKPase has been shown to mediate caspase-dependent apoptosis. CaMKPase can also interact with the Rho guanine nucleotide exchange factors (PIX) thereby blocking the effects of p21-activated kinase 1 (PAK1).

Gene Aliases:

PPM1F, FEM-2, hFEM-2, KIAA0015, POPX2

Genbank Number:

NM_014634

References:

1. Isamu, K. et al: Phosphorylation and activation of Ca2+/calmodulin-dependent protein kinase phosphatase by Ca2+/calmodulin-dependent protein kinase II. FEBS Letters,1999; 456: 249-252.

2. Ishida, A. et al: Stimulation of Ca2+/calmodulin-dependent protein kinase phosphatase by polycations. Archives of Biochemistry and Biophysics, 2002; 408:229-238.