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PI4K2A, Active

Recombinant full-length human PI4K2A was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P21-102G

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Catalog No. Pack Size Price (USD)
P21-102G-05 5 ug $259
P21-102G-10 10 ug $380
P21-102G-BULK BULK Contact Us  


PI4K2A or phosphatidylinositol 4-kinase type 2 alpha is involved in the formation of phosphatidylinositol-polyphosphates (PtdInsPs) which are centrally involved in many biologic processes ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4K2A phosphorylates PtdIns at the D-4 position which is an essential step in the biosynthesis of PtdInsPs. PI4K2A is a novel regulator of tumor growth by its action on angiogenesis and HIF-1alpha regulation. PI4K2A generates PtdIns4P-rich domains within the Golgi which regulate targeting of clathrin adaptor AP-1 complexes (1). PI4K2A is also required for Wnt to regulate LRP6 phosphorylation (2).

Gene Aliases:

DKFZp761G1923; PI4KII; PIK42A; RP11-548K23.6

Genbank Number:


1. Wang. et.al: Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi. Cell 114: 299-310, 2003.

2. Pan. et.al: Wnt3a-mediated formation of phospha-tidylinositol 4,5-bisphosphate regulates LRP6 phospho-rylation. Science 321: 1350-1353, 2008.

Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Molecular Weight:

~79 kDa

Product Datasheets


AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Lipid Kinases, Metabolic Disorder, NfkB Pathway, WNT Signaling


  Lipid Kinase Buffer, L01-09

  MnCl2 Solution, M40-09



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