PIP5K1B (phosphatidylinositol-4-phosphate 5-kinase, type I, beta) is a member of the phosphatidylinositol-4-phosphate 5-kinase family. PIP5K1B gene contains 17 exons and spans more than 300 kb. The seventeenth exon was found by RT-PCR, and are derived from the 3-prime untranslated region of the PRKACG gene which is located on 9q13 approximately 3 kb downstream of the STM7.I 3-prime untranslated region (1). The overexpression of PIP5K1B in COS-7 cells induces an increase in short actin fibers and a decrease in actin stress fibers(2).
1. Pook, M. A.et.al: Exon-intron structure of a 2.7-kb transcript of the STM7 gene with phosphatidylinositol-4-phosphate 5-kinase activity. Genomics 42: 170-172, 1997.
2. Ishihara, H.et.al: Type I phosphatidylinositol-4-phosphate 5-kinases: cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family. J. Biol. Chem. 273: 8741-8748, 1998.
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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