Diacylglycerol kinase epsilon (DAG kinase epsilon) is the only member of class III diacylglycerol kinase family, which lacks the E-F hand motifs for Ca+ binding but possess a clear selectivity for arachidonoyl-containing species of diacylglycerol (1). DGK epsilon might decrease signals conducted via arachidonoyl-diacylglycerol or promotes the synthesis of phospholipids with certain fatty acids (1). DGK epsilon contributes to Huntington disease pathogenesis and its inhibition might be effect in the therapeutics (2). Also, recessive mutations in DGKE results in unrestricted complement activation in atypical hemolytic-uremic syndrome (3).
DGK; AHUS7; DAGK5; DAGK6; NPHS7
1. Tang, W. et al. Molecular Cloning of a Novel Human Diacylglycerol Kinase Highly Selective for Arachidonate-containing Substrates. The Journal of Biological Chemistry. (271) 10237–10241, 1996.
2. Zhang, N. et al. Inhibition of Lipid Signaling Enzyme Diacylglycerol Kinase Epsilon Attenuates Mutant Huntingtin Toxicity. The Journal of Biological Chemistry. (287) 21204–21213, 2012.
3. Lemaire, M. et al. Recessive mutations in DGKE cause atypical hemolytic-uremic syndrome. Nature Genetics. (45) 531-536, 2013.
Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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