Diacylglycerol kinase beta (DAG kinase beta) is a member of class I diacylglycerol kinase family and is regulated by Ca+ (1). Via converting diacylglycerol into phosphatidic acid, diacylglycerol kinases decrease the diacylglycerol levels to regulate the activity of PKC, Rho and Ras families (2). DGK beta is localized in brain and is involved in emotion and long-term memory linked to cognitive function (3). Impaired levels of diacylglycerol by DGK beta limits the NADPH oxidase activation in phagosomes (4).
DGK; DAGK2; DGK-BETA
1. Merida, I. et al. Diacylglycerol kinases: at the hub of cell signaling. Biochem. J. (409), 1–18, 2008.
2. Kano, T. et al. Both the C1 domain and a basic amino acid cluster at the C-terminus are important for the neurite and branch induction ability of DGKb. Biochemical and Biophysical Research Communications. (447) 89–94, 2014.
3. Caricasole, A. et al. Molecular Cloning and Characterization of the Human Diacylglycerol Kinase beta (DGKb) Gene. The Journal of Biological Chemistry. (277) 4790–4796, 2002.
4. Schlam, D. et al. Diacylglycerol Kinases Terminate Diacylglycerol Signaling during the Respiratory Burst Leading to Heterogeneous Phagosomal NADPH Oxidase Activation. The Journal of Biological Chemistry. (288), 23090–23104, 2013.
Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, Inflammation, PKA/PKC Pathway