Overview:

Diacylglycerol kinase beta (DAG kinase beta) is a member of class I diacylglycerol kinase family and is regulated by Ca+ (1). Via converting diacylglycerol into phosphatidic acid, diacylglycerol kinases decrease the diacylglycerol levels to regulate the activity of PKC, Rho and Ras families (2). DGK beta is localized in brain and is involved in emotion and long-term memory linked to cognitive function (3). Impaired levels of diacylglycerol by DGK beta limits the NADPH oxidase activation in phagosomes (4).

Gene Aliases:

DGK; DAGK2; DGK-BETA

Genbank Number:

NM_004080

References:

1. Merida, I. et al. Diacylglycerol kinases: at the hub of cell signaling. Biochem. J. (409), 1–18, 2008.

2. Kano, T. et al. Both the C1 domain and a basic amino acid cluster at the C-terminus are important for the neurite and branch induction ability of DGKb. Biochemical and Biophysical Research Communications. (447) 89–94, 2014.

3. Caricasole, A. et al. Molecular Cloning and Characterization of the Human Diacylglycerol Kinase beta (DGKb) Gene. The Journal of Biological Chemistry. (277) 4790–4796, 2002.

4. Schlam, D. et al. Diacylglycerol Kinases Terminate Diacylglycerol Signaling during the Respiratory Burst Leading to Heterogeneous Phagosomal NADPH Oxidase Activation. The Journal of Biological Chemistry. (288), 23090–23104, 2013.