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DGKB, Active

Recombinant full-length human DGKB was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. D22-10G


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Catalog No. Pack Size Price (USD)
D22-10G-05 5 ug $226
D22-10G-10 10 ug $325
D22-10G-BULK BULK Contact Us  


Overview:

Diacylglycerol kinase beta (DAG kinase beta) is a member of class I diacylglycerol kinase family and is regulated by Ca+ (1). Via converting diacylglycerol into phosphatidic acid, diacylglycerol kinases decrease the diacylglycerol levels to regulate the activity of PKC, Rho and Ras families (2). DGK beta is localized in brain and is involved in emotion and long-term memory linked to cognitive function (3). Impaired levels of diacylglycerol by DGK beta limits the NADPH oxidase activation in phagosomes (4).


Gene Aliases:

DGK; DAGK2; DGK-BETA


Genbank Number:


References:


1. Merida, I. et al. Diacylglycerol kinases: at the hub of cell signaling. Biochem. J. (409), 1–18, 2008.

2. Kano, T. et al. Both the C1 domain and a basic amino acid cluster at the C-terminus are important for the neurite and branch induction ability of DGKb. Biochemical and Biophysical Research Communications. (447) 89–94, 2014.

3. Caricasole, A. et al. Molecular Cloning and Characterization of the Human Diacylglycerol Kinase beta (DGKb) Gene. The Journal of Biological Chemistry. (277) 4790–4796, 2002.

4. Schlam, D. et al. Diacylglycerol Kinases Terminate Diacylglycerol Signaling during the Respiratory Burst Leading to Heterogeneous Phagosomal NADPH Oxidase Activation. The Journal of Biological Chemistry. (288), 23090–23104, 2013.


Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

118 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, Inflammation, PKA/PKC Pathway


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