Diacylglycerol kinase theta (DAG kinase theta) is the only member of class V diacylglycerol kinase, which contains three cysteine-rich domains, a proline-rich region, and a Ras-associating domain and mediates the regeneration of phosphatidylinositol from diacylglycerol in cell signal transduction (1). DGKQ has been associated with Parkinson’s disease in a genome-wide meta-analysis study (2). Stimulated DGK theta activity promotes the SF1-dependent transcription of CYP17 in human adrenocortical cells (3).
DAGK; DAGK4; DAGK7
1. Houssa, B. et al. Cloning of a Novel Human Diacylglycerol Kinase (DGK theta) Containing Three Cysteine-rich Domains, a Proline-rich Region, and a Pleckstrin Homology Domain with an Overlapping Ras-associating Domain. The Journal of Biological Chemistry. (272) 10422–10428, 1997.
2. Nalls, M. et al. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson’s disease. Nature Genetics. (46) 989-993, 2014.
3. Li, Donghui. et al. Cyclic AMP-Stimulated Interaction between Steroidogenic Factor 1 and Diacylglycerol Kinase theta Facilitates Induction of CYP17. Molecular and Cellular Biology. (27) 6669–6685, 2007.
Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, Inflammation, PKA/PKC Pathway