DGKH is a type II DGK encoded by gene DGKH (1). Diacylglycerol kinases modulate the concentration of intracellular diacylglycerol by phosphorylating, producing phosphatidic acid (PA) (2). PA regulates signaling proteins, such as protein kinases and phosphatases, and can induce cell mitosis through regulation of growth factors (3). DGKH is a positive regulator of the epidermal growth factor receptor/Raf/MEK/ERK pathway. DGKH is associated with attention deficit hyperactivity disorder, unipolar depression and schizophrenia (4).
Diacylglycerol kinase eta; Diglyceride kinase eta
1. Rittiner, JE. et al: Overexpression of diacylglycerol kinase η enhances Gαq-coupled G protein-coupled receptor signaling. Mol Pharmacol. 2014; 85(5):800-810.
2. Ding, L. et al: The cloning and characterization of a novel human diacylglycerol kinase, DGKiota. J Biol Chem. 1998; 273(49):32746-52.
3. Buckland, AG. et al: Anionic phospholipids, interfacial binding and the regulation of cell functions. Biochim Biophys Acta. 2000; 1483(2):199-216.
4. Sakane, F. et al: Diacylglycerol kinases as emerging potential drug targets for a variety of diseases: An update. Front Cell Dev Biol. 2016; 4:82.
Sample Activity Plot. For specific information on a given lot, see the related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot targets into smaller quantities after centrifugation and store at the recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Approx. 165 kDa
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Apoptosis/Autophagy, Cancer, Cell Cycle, Cellular Stress, Lipid Kinases