Home   >    Proteins   >   Lipid Kinases

DGKI, Active

Recombinant full-length human DGKI was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. D27-10G


Shop Online



Catalog No. Pack Size Price (USD)
D27-10G-05 5 ug $226
D27-10G-10 10 ug $325
D27-10G-BULK BULK Contact Us  


Overview:

Diacylglycerol kinase iota (DGKI) is a member of the type IV diacylglycerol kinase subfamily. Diacylglycerol kinases modulate the concentration of intracellular diacylglycerol by phosphorylating, producing phosphatidic acid (PA) (1). PA regulates signaling proteins, such as protein kinases and phosphatases, and can induce cell mitosis through regulation of growth factors (2). DGKI has been shown to overexpress in a variety of cancers and is associated with poor prognosis in colon and gastric cancer (3).


Gene Aliases:

Diacylglycerol kinase iota; DGK-iota


Genbank Number:


References:


1. Ding, L. et al: The cloning and characterization of a novel human diacylglycerol kinase, DGKiota. J Biol Chem. 1998; 273(49):32746-52.

2. Buckland, AG. et al: Anionic phospholipids, interfacial binding and the regulation of cell functions. Biochim Biophys Acta. 2000; 1483(2):199-216.

3. Penrose, HM. et al: In colonic cells reduced mitochondrial function mediates transcriptomic alterations associated with cancer. Oncoscience. 2017; 4(11-12):189-198.


Specific Activity:

Sample Activity Plot. For specific information on a given lot, see the related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see the related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Cellular Stress, Inflammation, Invasion/Metastasis, Lipid Kinases


RELATED PRODUCTS


  DGKK, Active, D28-10G

  DGKH, Active, D26-10G

  DGKG, Active, D25-10G

  DGKE, Active, D24-10G


SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox