Diacylglycerol kinase iota (DGKI) is a member of the type IV diacylglycerol kinase subfamily. Diacylglycerol kinases modulate the concentration of intracellular diacylglycerol by phosphorylating, producing phosphatidic acid (PA) (1). PA regulates signaling proteins, such as protein kinases and phosphatases, and can induce cell mitosis through regulation of growth factors (2). DGKI has been shown to overexpress in a variety of cancers and is associated with poor prognosis in colon and gastric cancer (3).
Diacylglycerol kinase iota; DGK-iota
1. Ding, L. et al: The cloning and characterization of a novel human diacylglycerol kinase, DGKiota. J Biol Chem. 1998; 273(49):32746-52.
2. Buckland, AG. et al: Anionic phospholipids, interfacial binding and the regulation of cell functions. Biochim Biophys Acta. 2000; 1483(2):199-216.
3. Penrose, HM. et al: In colonic cells reduced mitochondrial function mediates transcriptomic alterations associated with cancer. Oncoscience. 2017; 4(11-12):189-198.
Sample Activity Plot. For specific information on a given lot, see the related technical data sheet.
Sample Purity Data. For specific information on a given lot, see the related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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Apoptosis/Autophagy, Cancer, Cellular Stress, Inflammation, Invasion/Metastasis, Lipid Kinases