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DGKK, Active

Recombinant full-length human DGKK was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. D28-10G


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Catalog No. Pack Size Price (USD)
D28-10G-05 5 ug $226
D28-10G-10 10 ug $325
D28-10G-BULK BULK Contact Us  


Overview:

Diacylglycerol kinase kappa (DGKK) is a member of the type II diacylglycerol kinase subfamily. Diacylglycerol kinases modulate the concentration of intracellular diacylglycerol by phosphorylating, producing phosphatidic acid (PA) (1). PA regulates signaling proteins, such as protein kinases and phosphatases, and can induce cell mitosis through regulation of growth factors (2). Genetic variants of DGKk are associated with hypospadias in mild and moderate Han Chinese cases (3).


Gene Aliases:

Diacylglycerol kinase kappa; DGK-kappa


Genbank Number:


References:


1. Imai, S. et al: Identification and characterization of a novel human type II diacylglycerol kinase, DGK kappa. J Biol Chem. 2005; 280(48):39870-81.

2. Buckland, A.G. et al: Anionic phospholipids, interfacial binding and the regulation of cell functions. Biochim Biophys Acta. 2000; 1483(2):199-216.

3. Xie, H. et al: Association between diacylglycerol kinase kappa variants and hypospadias susceptibility in a Han Chinese population. Asian journal of andrology. 2018; 20 (1): 85-89.


Activity:

Sample activity data. For lot specific data, please refer to the respective datasheet.


Purity:

Sample purity data. For lot specific data, please refer to the respective datasheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

MW 171kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Angiogenesis, Apoptosis/Autophagy, Cancer, Cell Cycle, Cellular Stress, Lipid Kinases, Neurobiology


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