HAT Inhibitor
Catalog No. K311-903
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| K311-903-5 | 5 mg | $120 | |
| K311-903-25 | 25 mg | $480 | |
| K311-903-BULK | BULK | Contact Us |
Overview:
Potent and selective inhibitor of the histone acetyl transferase p300/CBP (Ki=400 nM )1. Induces apoptosis in prostate cancer cells2. Enhances fear extinction memory and synaptic plasticity in mice3. Promotes tau deacetylation reducing levels of pathogenic p-tau4. Cell permeable.
References:
1. EM Bowers et al. Chem. Biol. 2010 17:471
2. FR Santer et al. Mol. Cancer Ther. 2011 10:1644
3. R Marek et al. J. Neurosci. 2011 31:7486
4. S-W Min et al. Neuron 2010 67:953
CAS Registry Number:
328968-36-1
Molecular Formula:
C24H19N3O6
Appearance:
Orange powder
Melting Point:
224-226oC
Molecular Weight:
445.4
Purity:
>98%
Solubilization:
May be dissolved in DMSO (10 mg/ml)
Aliases:
4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]benzoic acid
Storage and Stability:
Store desiccated as supplied at 4oC for up to 2 years. Store solutions at -20oC for up to 2 months.
Molecular Structure:
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There are no related publications available for this product.
Apoptosis/Autophagy, Cancer, Cancer, Cardiovascular Disease, Cell Cycle, Cell Cycle, ERK/MAPK Pathway, Inflammation, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, PKA/PKC Pathway
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