Tau proteins constitute a family of very important neuronal proteins that bind to the neuronal microtubules. As one of the first discovered and characterized microtubule-associated proteins, the role of Tau proteins has ever since been associated with an array of neuro-biochemical processes including formation and maintenance of neuronal transport system. Researchers have been constantly monitoring the role of myriad Tau proteins in neuronal pathways and their mutagenesis in neurodegenerative disorders such as Alzheimer’s disease.
Abnormal phosphorylation of Tau can lead to deposits of Tau filaments leading to severe pathogenesis in multiple neurodegenerative disorders such as Alzheimer’s disease. Over the years there has been an exponential boost in Tau research after multiple neurodegenerative diseases displayed tangled forms of Tau proteins in the brain. These observations have established Tau proteins as key potential therapeutic targets for neurodegenerative diseases and motivated scientists globally to invest their drug discovery efforts in understanding the Tau proteins and in developing novel therapeutics to modulate their functions.
Signalchem manufactures one of the most comprehensive selections of recombinant Tau proteins in the world. These include: various protein isoforms, phospho-Taus, and mutant variants. Our selection of a wide range of Tau proteins demonstrates SignalChem's drive to provide quality reagents to facilitate research in neurobiology and these proteins have so far been utilized in a variety of fields including neurodegeneration, oncology, epigenetics, cell stress, and more.