Epigenetic enzymes are crucial in maintaining key cellular functions by modifying chromatin structures and controlling gene transcription process. These reversible epigenetic DNA and histone modifications are controlled by important epigenetic enzymes such as methyltransferases and acetyltransferases. Dysregulation of these enzymes have been observed in myriad human diseases such as cancer. In recent years, epigenetic enzymes have emerged as some of the most promising classes of targets for drug discovery projects and development projects.
Scientists at SignalChem have developed a full range of epigenetic enzymes including acetyltransferases, histone deacetylases, methyltransferases and more. Our high-quality recombinant epigenetic enzymes and the assay methods are valuable tools for scientists to conduct research in epigenetics and for the pharmaceutical companies to develop novel therapeutics modulating these biological targets.
|Name||Catalog Number||Species||Tag||Expression System||Sequence||Genbank Number|
|BRD2 (BD2), Active||B16-31H||Human||HIS||E.coli||339-459||NM_005104|
|BRD4 (BD1), Active||B18-31H||Human||HIS||E.coli||49-170||NM_014299|
|BRD4 (BD2), Active||B18-38H||Human||HIS||E.coli||342-460||NM_014299|