Rabbit Polyclonal Antibody
Catalog No. C22-63R
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
C22-63R-100 | 100 ul | $675 | |
C22-63R-BULK | BULK | Contact Us |
Overview:
CDK1 or Cell Division Control protein 1 is essential for the completion of START, the controlling event in the cell cycle that is required to initiate mitosis. CDK1 is a catalytic subunit of a protein kinase complex, called the M-Phase Promoting Factor that induces entry into mitosis and is universal among eukaryotes (1). Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays the onset of apoptosis. Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer has also been demonstrated (2)
References:
1. Vantieghem, A. et al: Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays the onset of apoptosis. J. Biol. Chem. 2002; 277(40):37718-31.
2. Rigas, A.C. et al: Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer. Oncogene. 2007; 18.
Specificity:
Recognizes the 34kDa cdc2 protein
Cross Reactivity:
Human, Rat and Mouse
Host Isotype / Clone#:
Rabbit, Antiserum
Immunogen:
The antibody was produced against synthesized peptide corresponding to the C-terminus of the human protein conjugated to KLH.
Purification:
Delipidation and Defibrination
Stability:
1yr at –20oC from date of shipment
Sample Data:
Western blot using Anti-CDK1 antibody to detect CDK1 in MCF-7 cell lysates.
Ruiz Josue E et al., Meiotic Inactivation of Xenopus Myt1 by CDK/XRINGO, but Not CDK/Cyclin, via Site-Specific Phosphorylation Molecular Cell October 2008 10.1016/j.molcel.2008.08.029
M Kanke et al., Cohesin acetylation and Wapl-Pds5 oppositely regulate translocation of cohesin along DNA. EMBO Journal November 2016 10.15252/embj.201695756
Zhao Yulei et al., Regulation of sensitivity of tumor cells to antitubulin drugs by Cdk1-TAZ signalling Oncotarget May 2015 10.18632/oncotarget.4259
Dachineni Rakesh et al., Salicylic acid metabolites and derivatives inhibit CDK activity: Novel insights into aspirin's chemopreventive effects against colorectal cancer Int J Oncol. October 2017 10.3892/ijo.2017.4167
Bhandaria Deepali et al., Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration?proliferation dichotomy PNAS July 2015 10.1073/pnas.1514157112
Cancer, Cell Cycle, Ser/Thr Kinases
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