HDAC6 or Histone deacetylase 6 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. The protein encoded by this gene belongs to class II of the histone deacetylase family that regulates important biologic processes beyond histone metabolism and gene transcription (1). HDAC6 is a central component of the stress response that regulates SG formation and potentially contributes to control of RNA metabolism and translation (2).
HD6; JM21; KIAA0901
1. Hubbert, C. et.al: HDAC6 is a microtubule-associated deacetylase. Nature 417: 455-458, 2002.
2. Kwon, S. et.al: The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress response. Genes Dev. 21: 3381-3394, 2007.
Sample Histone Deacetylase Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
~ 180 kDa
Ishihara N Ageta et al., Septins promote dendrite and axon development by negatively regulating microtubule stability via HDAC6-mediated deacetylation. Nature Communications May 2013 10.1038/ncomms3532
Hou Xuben et al., Enhancing the Sensitivity of Pharmacophore-Based Virtual Screening by Incorporating Customized ZBG Features: A Case Study Using Histone Deacetylase 8 Journal of Chemical Information and Modeling March 2015 10.1021/ci500762z
Cancer, Cell Cycle, Inflammation